One of lithopone’s defining characteristics is its high hiding power, which rivals that of titanium dioxide in certain applications, making it ideal for opaque finishes. It exhibits good resistance to alkalis, though it is sensitive to acids, which can break down its structure. Unlike some pigments, lithopone does not discolor under light, ensuring long-term stability in outdoor and indoor products alike. Its low oil absorption also enhances its performance in paints and inks, allowing for smoother application and better flow.​

In the manufacturing process, purified barium sulfide and zinc sulfate solutions are mixed, precipitating the lithopone particles, which are then filtered, washed, dried, and ground to achieve precise particle sizes—usually ranging from 0.5 to 5 micrometers. This fine grinding enhances its dispersibility in various matrices, from oil-based paints to plastic resins.​

The coatings industry relies heavily on lithopone for interior paints, primers, and enamels, where it provides a uniform white base and improves coverage. In plastics, it acts as a filler and whitening agent in products like PVC pipes, toys, and packaging, enhancing both appearance and structural integrity. Cosmetics formulations, such as face powders and creams, use lithopone for its matte finish and ability to reflect light, giving skin a smooth, even tone.